Frequently Asked Questions
Science & Technology
What is recombinant humanized collagen?
A lab-engineered collagen protein designed to closely resemble human collagen, produced without animal-derived ingredients using recombinant DNA technology.
Is this the same collagen found in the human body?
It is recombinant human Type III collagen produced from the human collagen α-chain sequence (100% amino acid homology) manufactured via controlled fermentation.
Why is Colsigen™ not using animal-derived collagen?
Our formulations are based on biotechnology-derived, non-animal proteins to ensure consistency, safety, and ethical sourcing. This approach also minimizes the risk of immune reactions.
Isn't all collagen basically the same?
Not at all. Colsigen™ is based on recombinant humanized type III collagen, bio-identical to what’s naturally found in youthful human skin. Unlike collagen from animals, it offers precise compatibility, better bioavailability, and targeted skin regeneration.
Is Colsigen™ vegan?
Yes. Colsigen contains no animal-derived ingredients. The collagen is produced through recombinant biotechnology using a non-animal fermentation process.
What is the regulatory status of Colsigen™?
Colsigen™ is registered FDA and Swissmedic Class I Medical Device.
Composition & Safety
Is recombinant collagen safe?
Absolutely. It is produced through animal-free recombinant biotechnology in controlled bioreactors, it avoids animal-borne contaminants and ensures a high level of purity and consistency.
Are there fragrances or dyes in Colsigen™?
No. Colsigen™ products are fragrance-free and dye-free to reduce the risk of irritation and support use on sensitive or post-procedure skin.
Why should I use it post laser if it says it is contraindicated for wounds?
Colsigen™ is indicated for superficial wounds, not open wounds where the epidermis has been completely removed.
Can lab-made collagen cause allergies or side effects?
Recombinant humanized collagen is gentle:
– Free from animal-source collagen proteins: Because it is not derived from bovine or porcine sources, it avoids species-related immune reactions sometimes associated with animal collagen.
– Tested for safety: It has undergone rigorous in vitro and in vivo safety evaluations, including skin irritation and sensitization testing.
Why does Colsigen Mist™ have a noticeable odor?
Colsigen Mist™ is formulated without added fragrance. The perceived odor primarily originates from the natural scent of the mixed raw materials, and no masking fragrance is added. In spray form, the odor may be temporarily amplified, which is a normal phenomenon.
Why does Colsigen Mist™ cause coughing?
A possible reason is that Colsigen Mist™ is relatively finely dispersed; when used during inhalation, a small amount of the mist may enter the respiratory tract and trigger the body’s normal protective cough reflex.
It is recommended to apply Colsigen Mist™ at a distance of 15–20 cm from the face. Briefly holding the breath during spraying can significantly reduce this occurrence.
Are there any known side effects?
Colsigen™ is well-tolerated. There have been no side effects observed with the proper use of Colsigen™ products. In rare cases, minor irritation may occur due to individual sensitivities. Discontinue use if irritation persists.
I felt stinging after applying Colsigen Refresh™. Is this normal?
Yes. After procedures like laser treatments, the skin barrier is temporarily weakened. This allows products to penetrate more deeply and can briefly stimulate nerve endings, causing short-lived stinging.
Does this mean that Colsigen™ is irritating or unsafe?
No. The formula contains no fragrance, alcohol, or harsh ingredients and is designed to be gentle. During development, the product was also tested for irritation potential and other biocompatibility parameters, confirming it is safe and well tolerated. Temporary stinging on very sensitive or recently treated skin is a normal response.
How long should it last and when should I worry?
It usually fades within a few minutes. If you get strong pain, persistent redness, swelling, itching, or a rash, stop using it and contact your physician.
Is Colsigen® gluten-free?
Yes. Colsigen® does not contain gluten or gluten-derived ingredients.
Brand & Portfolio
Does Colsigen™ Portfolio replace Stratacel®?
No, Colsigen™ does not replace Stratacel®. Colsigen™ may be used in combination with Stratacel®: first apply Colsigen™ and let it dry, then apply Stratacel® on top to create a semi‑permeable protective barrier which may help maintain the benefits of the Colsigen™ mask ingredients.
Find more information about Stratacel here: www.stratacel.com
How does Colsigen™ fit within the Stratpharma portfolio?
Colsigen™ brings recombinant humanized type III collagen, a bioengineered, non-animal collagen formulated to soothe, hydrate, and rejuvenate sensitive or compromised skin, repairing the damage from cosmetic procedures and daily environmental stresses. Together with Stratpharma’s current offerings, Colsigen™ provides a complementary approach to support hydration and skin comfort.
Usage & Application
How should I use Colsigen Refresh™?
Cleanse your face thoroughly with lukewarm water. Apply the mask gently to your clean, dry skin. Relax for 20 minutes while the mask works. Allow to absorb naturally or pat in gently for extra hydration and glow.
How should I use Colsigen Mist™?
Cleanse your face thoroughly with lukewarm water. Hold the bottle 15–20 cm away from your face. Spray evenly across the skin, keeping eyes closed. Allow to absorb naturally or pat in gently for extra hydration and glow.
Can Colsigen™ be used after cosmetic procedures?
Yes. They are commonly used post-treatment for hydration and comfort, but they are not intended for open wounds. Always consult with your HCP.
Can Colsigen® be used after ablative laser procedures, or only fractional lasers?
Colsigen® can be used following both ablative and fractional laser resurfacing procedures. It is suitable for compromised skin after aesthetic treatments and integrates easily into post-procedure protocols. Colsigen® is as class I Medical Device made from non-animal derived materials, fragrance and alcohol-free and is formulated with injectable grade materials reducing the risk of reaction.
How often can Colsigen Refresh™ and Colsigen Mist™ be used?
Both can be used daily or as needed, even multiple times per day in the case of Colsigen Mist™. They are safe for regular use on all skin types.
Can Colsigen Mist™ be used under makeup?
Yes, it can be used under or over makeup as a hydration boost.
Is Colsigen™ suitable for sensitive or post-procedure skin ?
Yes. Colsigen™ is formulated for sensitive skin and has been tested for irritation potential and biocompatibility during development, confirming it is safe and well-tolerated.
Can I refrigerate the mask for extra cooling?
Use Colsigen Refresh™ at room temp; if stinging, gently warm the unopened sachet in hands before application.
Who are the ideal users for Colsigen™?
- Patients’ post-cosmetic procedures (laser resurfacing, microdermabrasion, microneedling, superficial peels…)
- Individuals with sensitive, dry, or stressed skin
- Everyday use, for all skin types
Is Colsigen™ suitable for retail resale in aesthetic practices?
Colsigen™ is specifically designed to be clinic and retail ready. It is available in Box of 5 single-use masks and Box of 25 single-use masks, and can be sold either as a complete unit or as individual sachets, which are individually barcoded and UDI-labeled. This flexible format makes Colsigen™ ideal for post-procedure aftercare programs, in-clinic resale, bundled treatment packages, and professional aesthetic retail environments.
Storage & Stability
How should Colsigen™ be stored?
Colsigen™ does not require any special storage conditions under normal use.
How long can Colsigen™ be used?
Colsigen™ has a 36‑month shelf life from the manufacturing date when stored properly. Please refer to the expiry date printed on each package to ensure it is still within this period.
Note for Colsigen Refresh™: Once the sachet is opened, it will dry out quickly—use immediately for best results.
Does temperature affect recombinant collagen stability?
No, temperature does not significantly affect recombinant collagen stability in Colsigen™ under normal storage and use conditions.
Colsigen™ vs Other Ingredients
How is Colsigen™ different from traditional collagen products?
Traditional products often use animal-derived collagen, which may vary in purity and compatibility. Colsigen™ uses recombinant humanized collagen, offering better safety, consistency, and performance for sensitive and post-procedure skin. Many collagen skincare products are marketed as cosmetics and focus on surface-level hydration. Colsigen™ is positioned as a medical device that helps support the skin’s moisture barrier and repair processes, rather than acting as a traditional cosmetic moisturizer.
How is Colsigen™ formulation different from Hyaluronic Acid (HA)?
Unlike hyaluronic acid, which mainly acts as a humectant, Colsigen™ forms a structured, breathable collagen film at the skin surface. This matrix supports moisture retention and creates a protective environment that facilitates the skin’s natural repair processes after superficial procedures.
How is Colsigen™ formulation different from Centella Asiatica?
Colsigen™ offers fundamentally different support compared to Centella Asiatica. Centella is a great botanical soother that helps calm inflammation. Colsigen™, by contrast, features recombinant humanized type III collagen in a protective, bioactive film that hydrates and comforts compromised skin while supporting barrier function.
How is Colsigen™ formulation different from Niacinamide?
Colsigen™ provides immediate structural support by forming a collagen film at the skin surface. Niacinamide supports barrier function through biochemical pathways over time, but does not create a protective matrix.
How is Colsigen™ formulation different from Aloe Vera?
Aloe vera mainly offers surface-level soothing and hydration, with temporary calming effects but no collagen structure or targeted repair for compromised skin. Colsigen™ contains humanized type III collagen that forms a biomimetic, bioactive film—hydrating, soothing, and actively supporting barrier restoration and skin regeneration in a medical-grade way.
How is Colsigen™ different from traditional collagen creams and serums?
Traditional collagen creams and serums primarily provide surface hydration and temporary plumping effects. They typically contain hydrolyzed bovine or marine collagen, which functions mainly as a moisturizing ingredient. Colsigen™, by contrast, contains recombinant humanized Type III collagen that forms a structured, breathable film on the skin surface. This biomimetic matrix supports moisture retention and provides a protective environment that facilitates the skin’s natural recovery processes.
How is Colsigen™ different from collagen injections?
Traditional collagen injections are invasive, localized, higher risk, and focus mainly on adding volume rather than overall skin comfort and recovery. Colsigen™ provides medical‑grade skin recovery without needles, downtime, or animal-derived collagen. It contains recombinant humanized type III collagen that forms a film over the entire treated area, hydrating, soothing, and supporting barrier repair.
How is Colsigen™ different from collagen wound dressing?
Traditional collagen dressings are typically bovine or porcine type I, acting mainly as a passive scaffold that absorbs exudate and protects the wound surface. Colsigen™ uses non-animal derived humanized type III collagen, so it more closely mimics the skin’s own repair matrix than traditional collagen dressing. Colsigen™ instead forms a biomimetic collagen film that hydrates, soothes, and supports barrier restoration and tissue regeneration, making it especially suited for post‑procedure and sensitive skin.
Where to Buy?
Is Colsigen™ available in all countries?
At the moment, Colsigen™ is available in the United States and in Switzerland. We will provide updates as it becomes available in additional countries. You can also check our webshop: www.stratpharma-shop.com and select your country to see whether Colsigen™ is currently available in your region.
Is Colsigen™ available through clinics as well as retail channels?
Yes. Colsigen™ is available through aesthetic and dermatology clinics, where it can be incorporated into professional treatment protocols and post-procedure care. Please ask your clinic if Colsigen™ is available in your area. Alternatively, you can also easily order Colsigen™ from our online store at: www.stratpharma-shop.com.